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PrEP 2-1-1 is not a separate medication from the usual types of PrEP. It refers to the dosing schedule followed by individuals opting for PrEP 2-1-1. Instead of taking a pill every day, this method involves taking PrEP before and after sexual encounters.PrEP, short for pre-exposure prophylaxis, is highly effective in preventing HIV transmission. Maintaining a daily PrEP regimen can reduce the risk of HIV infection by 99%. However, for some individuals, adhering to a daily PrEP regimen may be challenging or even impossible.

Fortunately, there is an alternative option for those engaging in anal or vaginal sex to protect themselves from contracting HIV. It's known as PrEP 2-1-1. This approach involves taking PrEP before and after sexual encounters. If you want to learn more about PrEP 2-1-1, the team at PrEP2Me can provide you with further information. Let's address some frequently asked questions about PrEP 2-1-1, including its effectiveness during anal or vaginal sex and its relevance for individuals who engage in injection drug use.

What is 2 1 1 PrEP (Also known as PrEP 2-1-1)?

PrEP 2-1-1 is not a different medication than the usual types of PrEP. 2-1-1 simply refers to the schedule by which those opting for the PrEP 2-1-1 take their medicine. Instead of taking one pill every day, here’s how this method works:

  • Take two pills 2-24 hours before sex, which is particularly relevant for individuals engaged in injection drug use. Closer to 24 hours before sex is better.
  • Continue to take one pill every 24 hours to reduce the risk of getting HIV, especially for those involved in injection drug use.
  • Once you stop having sexual encounters, take two final doses 24 hours apart, ensuring adequate protection against HIV transmission.
  • It is important to note that a regular HIV test is crucial for individuals engaging in injection drug use to monitor their HIV status and assess the effectiveness of this PrEP regimen.

Using this method, individuals involved in injection drug use can build up enough antiviral power to benefit from all the protection of a typical PrEP regimen without having to take pills every single day.

Are There Other Differences Between PrEP 2-1-1 and Daily PrEP?

Yes. While some forms of daily PrEP are approved for use during any kind of sex, PrEP 2-1-1 has only been studied and approved to protect against anal sex. If you’re having receptive vaginal sex, you won’t be saved using 2-1-1 and should opt for a daily PrEP regimen. It is crucial to consult with a healthcare provider to discuss the most suitable PrEP option based on your specific needs and sexual activities. Additionally, it is essential to remember that PrEP does not protect against other sexually transmitted infections. If you are HIV-negative and engage in activities such as injecting drugs, it is recommended to discuss comprehensive prevention strategies with your healthcare provider. It is also worth mentioning that PrEP may not be suitable for individuals with chronic Hepatitis B or those who are on Hormone Replacement Therapy (HRT) taking testosterone or estradiol.

Are There Similarities Between 2 1 1 PrEP and Daily PrEP?

Yes! Individuals who choose to take PrEP using the 2-1-1 method will still need to undergo HIV and other STD testing every three months, just like those who take daily PrEP. Your prescription will likely be written for daily dosing to avoid potential coverage denials for 'off-label' medication. Moreover, the side effects of taking PrEP via the 2-1-1 method versus daily PrEP are virtually the same. Importantly, correctly following the 2-1-1 PrEP scheduling will provide you with the same 99% protection against HIV as taking a pill daily. This is particularly relevant when considering health insurance plans that cover prep pills.

Why Might I Want to Try 2-1-1?

PrEP 2-1-1 offers a convenient solution for individuals who find it challenging or unnecessary to take a daily pill. It is particularly beneficial for those who:

  • Have infrequent sexual activity or limited partners
  • Can anticipate when they will engage in sexual encounters
  • Are comfortable planning sexual encounters at least two hours in advance

By following the PrEP 2-1-1 schedule, you can protect yourself on your terms. If you want to start PrEP on this schedule, PrEP2Me provides an accessible online platform. Our services include an initial at-home STI test, telemedicine consultations with an HIV specialist, and prescription delivery to your doorstep. If you have questions about PrEP 2-1-1, please call us at (412) 844-7737. We are here to help and prescribe PrEP for individuals engaging in sex or injection drug use.

If you believe you may have had a high-risk encounter, you’re in Pennsylvania or Ohio, and you would like to get tested for HIV, don’t wait. As soon as you can, visit Central Outreach Wellness Center to see culturally competent HIV doctors near you.

Get started with PrEP2Me, where we make staying safe easy and accessible for everyone!

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